POM121 Drives Gastric Cancer Progression via the mTOR/p70S6K Signaling Axis

Anticancer Research 2026

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Authors: Hong-Beum Kim, SEONG-HUN KIM, Hye-Hwa Lee, HEE-JEONG LEE, Sang-Gon Park
DOI: 10.21873/anticanres.17987
Cited by: 0

Abstract

BACKGROUND/AIM: and its involvement in signaling pathways driving tumor progression. MATERIALS AND METHODS: xenograft models. Phosphorylation of p70S6 kinase at Thr389 and Thr421/Ser424 was examined to determine downstream signaling. RESULTS: attenuated phosphorylation of p70S6K at Thr389 and Thr421/Ser424, indicating impaired mTOR-p70S6K signaling. CONCLUSION: as a novel oncogene, prognostic biomarker, and potential therapeutic target in GC.

Fields of Study & Subjects

PI3K/AKT/mTOR signaling in cancer Gastric Cancer Management and Outcomes Cancer Mechanisms and Therapy

Publication details

Journal / source
Anticancer Research
Volume
46
Issue
2
Pages
787–795
Publication date
30 January 2026
Language
EN