Describing the Mutational Characteristics of Myxofibrosarcoma: An AACR Project GENIE Analysis

Background/Aim: Myxofibrosarcomas (MFS) are highly infiltrative soft tissue sarcomas that most commonly occur in adults within the sixth to seventh decades. Diagnosis relies on histopathological analysis as no definitive molecular markers have been identified. This study seeks to describe the mutational landscape of MFS, characterize mutations unique to certain populations, and identify mutations that may be of particular utility in diagnosis and treatment. Patients and Methods: Using the AACR Project GENIE database, we identified a cohort of 202 patients with MFS. Patients were stratified by sex, age, race, and ethnicity. Tumors were categorized as primary, metastatic, locally recurrent, or distant organ metastases. Somatic mutations and copy number alterations were identified. Data were analyzed using R and RStudio, with p