Postmenopausal Stage IV Ovarian Yolk Sac Tumor With Neuroendocrine Features: Report of a Rare Case

BACKGROUND/AIM: Ovarian yolk sac tumors (YSTs) are highly uncommon in postmenopausal women and may show unusual morphological patterns, including neuroendocrine differentiation. Such presentations are exceptionally rare and poorly characterized. CASE REPORT: We report the case of a 75-year-old woman presenting with a pelvic mass and diffuse peritoneal and hepatic involvement. Histopathological evaluation revealed a yolk sac tumor with mixed architectural features and focal chromogranin A expression, consistent with neuroendocrine differentiation. The disease was classified as FIGO stage IVB. The patient started first-line chemotherapy with a dose-adjusted combination of bleomycin, etoposide, and cisplatin, tailored to her age and overall condition. CONCLUSION: This case illustrates a particularly rare and aggressive presentation of ovarian YST in a postmenopausal patient. Early recognition, accurate pathological characterization, and individualized treatment are essential, although prognosis remains poor in this setting. Reporting such cases is crucial to improve understanding and management of these exceptional tumors.