Expression of YME1 Like 1 ATPase Increases With the Stage of Adrenocortical Carcinoma Tissue and Is Associated With Poor Patient Prognosis

Background/Aim: Adrenocortical carcinoma (ACC) is an endocrine tumor arising in the adrenal cortex. Although its incidence is extremely low, it is highly malignant, rapidly proliferating, and infiltrating surrounding organs, resulting in a poor prognosis. YME1 Like 1 ATPase (YME1L1) is an ATP-dependent metalloprotease that regulates mitochondrial proteostasis. Recently, a correlation between YME1L1 expression and the prognosis of several cancers has been reported. However, no studies have examined the expression level of YME1L1 mRNA in ACC tissues or the relationship between YME1L1 expression and the prognosis of ACC patients. Therefore, there is a need to investigate the relationship between YME1L1 expression and the prognosis of ACC patients. Materials and Methods: YME1L1 mRNA expression and survival in ACC patients were analyzed using the TCGA database with the UALCAN and GEPIA platforms. Results: YME1L1 mRNA expression was significantly increased in ACC tissues from stage IV patients compared with stage I, II, and III patients (p