Expression of Vascular Endothelial Growth Factor A in Gallbladder Cancer Cells: A Clinicopathological Study

Anticancer Research 2026

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Authors: Takafumi Okayama, T. Taniguchi, Takahiro Tomosugi, Ryuichiro Kimura, Atsushi Fujii, Yusuke Watanabe, Noboru Ideno, Naoki Ikenaga, Kohei Nakata, Takeo Yamamoto, YOSHINAO ODA, MASAFUMI NAKAMURA
DOI: 10.21873/anticanres.18053
Cited by: 0

Abstract

Background/Aim: Vascular endothelial growth factor (VEGF) is a key mediator of tumor angiogenesis. However, the clinicopathological and prognostic significance of VEGF expression gallbladder cancer (GBC) remains incompletely defined. This study evaluated the significance of VEGF expression in resected GBC specimens. Patients and Methods: We retrospectively reviewed 53 patients who underwent curative resection for GBC between 2001 and 2019. VEGF expression was evaluated using immunohistochemistry (IHC) in carcinoma tissues and paired non-cancerous mucosa. Results: VEGF positivity was more frequent in carcinomas than in non-cancerous mucosa [24/53 (45%) vs. 6/46 (13%); p

Fields of Study & Subjects

Cholangiocarcinoma and Gallbladder Cancer Studies Angiogenesis and VEGF in Cancer Gallbladder and Bile Duct Disorders

Publication details

Journal / source
Anticancer Research
Volume
46
Issue
3
Pages
1583–1589
Publication date
27 February 2026
Language
EN