Inhibition of AP-1 Reduces CD46-mediated Invasion of Bladder and Colon Cancer Cells

Anticancer Research 2026

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Authors: Thủy Nguyễn Thị, Van‐Tan Nguyen, Hien Duong Thanh, Se-Young Kwon, Jin-Hyung Cho, Changjong Moon, Chaeyong Jung
DOI: 10.21873/anticanres.18135
Cited by: 1

Abstract

BACKGROUND/AIM: the inactivation of MMP9. MATERIALS AND METHODS: Both bladder and colon cancer cells were used for western blot analysis and reporter transcription assays. AP-1 inhibitors used are AP-1 decoy oligonucleotide (AP1-ODN) and AP-1 specific inhibitor (SR11302). To test AP-1-mediated inhibition of cell migration and invasion, both wound healing scratch assay and transwell chamber assays with or without gelatin coating were utilized. RESULTS: . CONCLUSION: Targeting AP-1 can effectively suppress CD46-mediated invasion and metastasis in bladder and colon cancers, in which CD46 is generally overexpressed.

Fields of Study & Subjects

Protease and Inhibitor Mechanisms Signaling Pathways in Disease Peptidase Inhibition and Analysis

Publication details

Journal / source
Anticancer Research
Publisher
International Institute of Anticancer Research
Volume
46
Issue
5
Pages
2525–2539
Publication date
28 April 2026
Language
EN