Immunohistochemical Expression of Endoplasmic Reticulum Stress Markers and their Association With Clinicopathological Characteristics and Survival Outcomes in Endometrial Cancer

Cancer Diagnosis & Prognosis 2026 Open access

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Authors: Stefanos Flindris, Chrysoula Margioula‐Siarkou, Chrysoula Gouta, KONSTANTINOS CHRISTOPOULOS, Georgia Margioula‐Siarkou, Emmanouela-Aliki Almperi, Aristarchos Almperis, Alexandros Traianos, Michail Kalinderis, ELENI SAKELLARIOU, Konstantinos Flindris, Charalampos Karachalios
+7 more Effrosyni Styliara, Stamatia Angelidou, Konstantinos D. Pantazis, Iordanis Navrozoglou, Konstantinos D. Dinas, Georgios Markozannes, Stamatios Petousis
DOI: 10.21873/cdp.10531
Cited by: 0
References: 33

Abstract

Background/Aim: This study aimed to examine the immunohistochemical expression of Inositol-Requiring Enzyme 1 Alpha (IRE1) and Protein Kinase R-like ER Kinase (PERK) immunoreactivity scores (IRS) as emerging biomarkers on key clinicopathologic features and survival outcomes in endometrial cancer (EC). Patients and Methods: Immunoreactive scores (IRS) for IRE1 and PERK were assessed in tumor samples from 73 EC survivors and compared with 20 benign endometrial controls. Associations between IRS values and clinicopathological variables were analyzed. Overall survival (OS) and disease-free survival (DFS) were evaluated using univariable and multivariable Cox proportional hazards models adjusted for age, FIGO stage, and tumor grade. Results: IRE1-IRS and PERK-IRS were significantly higher in EC survivors compared to controls (p=0.015 and p

Fields of Study & Subjects

Endoplasmic Reticulum Stress and Disease Endometrial and Cervical Cancer Treatments Breast Cancer Treatment Studies

Publication details

Journal / source
Cancer Diagnosis & Prognosis
Volume
6
Issue
2
Pages
322–334
Publication date
1 March 2026
Language
EN