Effects of Isthmus Topography on the Molecular Characteristics of BRAF -mutant Papillary Thyroid Cancer
Abstract
BACKGROUND/AIM: Previous studies suggest that thyroid cancers in the isthmus are associated with more aggressive behavior and unfavorable patient outcomes compared to lobar tumors. This study aimed to characterize the molecular features of isthmus thyroid cancer. MATERIALS AND METHODS: V600E mutation located in the isthmus to 30 tumors in the unilateral lobar area. RESULTS: . Hierarchical proteomic clustering highlighted increased co-expression of several oncoproteins and DNA damage response markers in isthmus tumors. CONCLUSION: -mutant papillary thyroid cancers in the isthmus display distinct molecular characteristics, including increased ERK signaling activity. These findings suggest that topographical location independently influences tumor biology and may account for the more aggressive clinical behavior of isthmus tumors at the molecular level.
Fields of Study & Subjects
Thyroid Cancer Diagnosis and Treatment
S100 Proteins and Annexins
Caveolin-1 and cellular processes
Publication details
- Journal / source
- Cancer Genomics & Proteomics
- Publisher
- International Institute of Anticancer Research
- Volume
- 23
- Issue
- 3
- Pages
- 470–482
- Publication date
- 29 April 2026
- Language
- EN