Laryngeal and Hypopharyngeal Malignancies: Where Do We Stand? A Retrospective Single-center Study

In Vivo 2026 Open access

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Authors: Petr Škopek, David Slouka, Břetislav Gál, Miroslav Tedla, Martin Pešta, ALENA SKALOVA, Radek Kučera, Pavel Klail, Tomáš Kostlivý
DOI: 10.21873/invivo.14204
Cited by: 1

Abstract

Background/Aim: Squamous cell carcinoma (SCC) of the larynx and hypopharynx shows subsite-specific patterns, with supraglottic tumors closely resembling hypopharyngeal SCC. This study aimed to analyze 10-year epidemiologic trends, management, and outcomes in a tertiary hospital, with emphasis on prognostic similarities between supraglottic and hypopharyngeal tumors. Patients and Methods: A retrospective cohort of 454 patients with laryngeal or hypopharyngeal SCC (2012-2022) was evaluated. Demographic characteristics, TNM stage, treatment modality, and 5-year disease-specific survival (DSS) were analyzed. Results: Hypopharyngeal SCC cases were predominantly advanced (T3-T4: 66.4%; N2-N3: 82.7%) and more often metastatic (29.8%), compared with laryngeal SCC (40.6%, 21.1%, and 5.4%, respectively; p

Fields of Study & Subjects

Head and Neck Cancer Studies Cholangiocarcinoma and Gallbladder Cancer Studies Cancer Diagnosis and Treatment

Publication details

Journal / source
In Vivo
Publisher
International Institute of Anticancer Research
Volume
40
Issue
1
Pages
398–410
Publication date
1 January 2026
Language
EN