Microarray Analysis of Human Abdominal Aortic Aneurysm With Emphasis on Cardiovascular Genes Revealed Differentially Expressed Genes

In Vivo 2026 Open access

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Authors: Song Lu, LI PING LI, John Valery White, Xiaoying Zhang, Ifeyinwa Nwaneshiudu, Adaobi Nwaneshiudu, Nectaria Ntaoula, John Gaughan, Dimitri S. Monos, W Michael Lin, Charalambos Solomides, Emilia L. Oleszak
+1 more Chris D. Platsoucas
DOI: 10.21873/invivo.14286
Cited by: 1

Abstract

BACKGROUND/AIM: . normal aortas by cDNA microarray and real-time quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR). MATERIALS AND METHODS: P)-labeled cDNA from AAA specimens (mean AAA size 6.65 cm) and normal aortas were hybridized with a 588-gene microarray primarily of the cardiovascular system. The results were validated by qRT-PCR. RESULTS: ) was downregulated. CONCLUSION: . Remaining results confirmed previous reports regarding 21 genes differentially expressed in AAA. qRT-PCR results were in general in agreement with microarray results.

Fields of Study & Subjects

Aortic aneurysm repair treatments Gene expression and cancer classification Tissue Engineering and Regenerative Medicine

Publication details

Journal / source
In Vivo
Publisher
International Institute of Anticancer Research
Volume
40
Issue
3
Pages
1327–1347
Publication date
28 April 2026
Language
EN