Protocol for a Sequential Multiple Assignment Randomized Trial to Improve Physical Activity and Diet Quality in Survivors of Cancer

JMIR Research Protocols 2026 Open access

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Authors: Eric Jessen Chow, Ethan D Lee, Marie Hershberger, Kari M. Jenssen, Chongzhi Di, David Doody, Bridget Hogue, Jason A. Mendoza, Tammy Muller, Jeannette M. Schenk, Karen Leslie Syrjala, Yueqi Xu
+5 more Jean C. Yi, Ying‐Qi Zhao, Gregory T. Armstrong, Marian L. Neuhouser, Kevin Charles Oeffinger
DOI: 10.2196/104572
Cited by: 1
References: 57

Abstract

Background: Survivors of childhood cancer have an increased risk of cardiovascular disease (CVD), but that risk may be reduced by healthy lifestyle behaviors. Objective: Using a sequential multiple assignment randomized trial (SMART) design, this study aims to test different approaches to improve physical activity (PA) and diet quality among long-term survivors of cancer at increased risk of CVD over a 12-month period. The primary study outcomes are sedentary time and Healthy Eating Index (HEI) scores. Methods: Participants were recruited from the Childhood Cancer Survivor Study cohort, with eligibility defined as current age of 18 to 54 years and at least one of three self-reported criteria: (1)

Fields of Study & Subjects

Childhood Cancer Survivors' Quality of Life Chemotherapy-induced cardiotoxicity and mitigation Cancer survivorship and care

Publication details

Journal / source
JMIR Research Protocols
Publisher
JMIR Publications Inc.
Volume
15
Pages
e104572–e104572
Publication date
13 August 2026
Language
EN