AI-generated Feedback Following Social Robotic Virtual Patient Interactions and Medical Student Performance: Nonrandomized Quasi-Experimental Study

BACKGROUND: Virtual patients (VPs) demonstrate effectiveness in improving clinical reasoning skills; however, traditional VP platforms often lack individualized feedback mechanisms. Advances in large language models (LLMs) enable automated analysis of student-VP interactions, providing scalable feedback on clinical performance. While artificial intelligence (AI)-enhanced social robotic VP platforms show promise for clinical reasoning training, no studies have examined whether AI-generated feedback integrated in such platforms improves clinical performance in standardized assessments. OBJECTIVE: This study evaluated whether AI-generated postconsultation feedback integrated into social robotic VP interactions improves medical students' clinical performance, emphasizing medical history taking and communication. METHODS: A quasi-experimental study with 115 sixth-semester medical students (N=157, 73.2% of eligible students) was conducted at Karolinska Institutet, Stockholm, Sweden, during spring 2025. Students were allocated by hospital site to receive (n=61, 53%) or not receive (n=54, 46.9%) AI-generated feedback following interactions with a Social AI-Enhanced Robotic Interface. All students completed 9 VP cases; the intervention group received approximately 1 page of structured feedback after each VP case. The feedback system used multiple LLMs following a 2-stage algorithm: assessing student-VP dialogues using an assessment rubric, then generating structured feedback on history-taking performance. Both groups participated in case-specific follow-up seminars led by consultant rheumatologists following each VP encounter. Clinical performance was assessed through an 8-minute objective structured clinical examination (OSCE)-based evaluation, with a standardized patient portraying axial spondylarthritis, evaluated by a blinded consultant rheumatologist using a 10-point rubric across 5 domains: communication at consultation start, generic medical history, targeted medical history, diagnostics and management reasoning, and communication at consultation end. RESULTS: Students receiving AI-generated feedback achieved significantly higher total OSCE scores (mean 7.39, SD 0.86 vs mean 6.68, SD 1.04 points; mean difference 0.70; 95% CI 0.35-1.06; P