Yoruba Moral Philosophy and the Ethical Governance of Data Science Health Research in Africa (Preprint)

UNSTRUCTURED Data science health research (DSHR) which encompasses genomic biobanking, algorithmic clinical prediction, large-scale secondary use of health data, and AI-assisted diagnostics is expanding rapidly across Africa through initiatives such as the Human Heredity and Health in Africa (H3Africa) consortium and the Data Science for Health Discovery and Innovation in Africa (DS-I Africa) program. Existing ethical governance frameworks based on Western principlism, Ubuntu-based bioethics, and the CARE Principles for Indigenous Data Governance each capture part of the ethical terrain for governance of DSHR in Africa but gaps remain. In this paper, we apply a Yoruba moral philosophical framework, developed in a companion paper, to the five central challenges of DSHR governance: informed consent in big-data contexts, algorithmic fairness, data sovereignty, secondary use of health data, and AI clinical decision support. Drawing on the six Yoruba moral principles that extend principlism including procedural communal deliberation (Ifọgbọntáayésé), moderate-communitarian relational personhood, virtue-based character ethics (Ìwà/Omolúàbí), intergenerational kinship obligations (Àjọbí), sacred-epistemic confidentiality (Awo), and restorative-adjudicative justice (Ìlàjà), we demonstrate that each generates concrete, operationalizable governance recommendations that exceed what principlism, Ubuntu-bioethics, or CARE Principles supply individually. We present a comprehensive governance framework with specific institutional mechanisms: Community Data Stewardship Councils, tiered consent with lineage-level governance, Omolúàbí-informed researcher assessment, ẹbọ-based benefit-sharing, Awo-governed data classification, and ìlàjà restorative harm remediation. The framework positions Yoruba moral philosophy as one voice in a principled pluralism for ethical governance of DSHR in Africa. It is not a replacement for existing approaches but a substantive addition to the current governance landscape.