Holistic and economic benefits of comprehensive obesity care: 6 month real-world outcomes from a digital UK Tier-3 service (Preprint)

BACKGROUND Obesity is a complex chronic disease that disproportionately affects people living in socioeconomic deprivation. Although randomised trials demonstrate the efficacy of pharmacological and digital interventions, evidence on their real-world effectiveness regarding behavioral mechanisms, holistic health outcomes, and economic impact in routine care settings remains limited. OBJECTIVE This real-world evidence study evaluated 738 adults enrolled in the Oviva UK Tier-3 digital service. METHODS Outcomes at baseline, 3 and 6 months included body weight, lifestyle behaviors, psychosocial health, sickness-related absence from work, healthcare use, and engagement with Oviva App. Correlational and multivariable models examined predictors of weight change. RESULTS Participants achieved clinically meaningful weight loss (-2.7% at 3 months; -8.6% at 6 months). Improvements were also observed across general and mental health, physical functioning, quality of life, dietary habits, alcohol intake, sickness-related absence, and healthcare utilisation (all P