Effects of Synbiotic Supplementation on Blood and Urinary Concentrations of Factors Related to Kidney Stone Formation in Overweight or Obese Patients with Hyperoxaluria: A Randomized Controlled Trial.

PURPOSE: This study investigated the impact of synbiotics on blood and urinary concentrations of factors related to kidney stone formation in overweight or obese patients with hyperoxaluria. MATERIALS AND METHODS: A randomized double-blind clinical trial was conducted involving forty-four patients assigned to either synbiotic or placebo groups. Participants received their respective capsules twice daily for 12 weeks. Blood and 24-hour urine samples were collected at baseline and week 12 for biochemical analyses. RESULTS: Urinary oxalate significantly decreased in the synbiotic group compared with both baseline (P=.001) and placebo (P=.001). Other biochemical markers showed no significant differences, while urine volume increased in both groups without between-group variance. CONCLUSION: Synbiotic supplementation significantly reduced urinary oxalate but did not affect other blood or urinary parameters associated with kidney stone formation.