Protective effect of Pistacia lentiscus L. gum on pentylenetetrazol-induced seizures: Evaluation of antioxidant capacity in the hippocampus of male rats.

Objective: L. (Mastaki), from the Anacardiaceae family, is known for its polyphenolic properties. Regarding its role in oxidative stress, we aimed to investigate its beneficial effects on pentylenetetrazol (PTZ) model of acute seizure. Materials and Methods: L. gum (100, 200, or 400 mg/kg), 40 min before a single intraperitoneal injection of PTZ. Finally, hippocampal tissues were assessed for the determination of oxidative stress parameters. Results: also decreased elevated malondialdehyde (MDA) levels induced by PTZ and increased glutathione (GSH) concentration, and superoxide dismutase (SOD) and catalase (CAT) activities in comparison with the PTZ group. Conclusion: L. possesses anticonvulsant properties, which may be partially attributed to its antioxidant activity, offering protection against oxidative stress.