Herbal adjuvant therapy with a combination of Green Tea, Persian Borage, and Purslane to reduce antipsychotic-induced weight gain in Schizophrenia: A randomized controlled trial.

Objective: Second-generation antipsychotics can lead to metabolic problems. This study investigated whether an herbal compound with green tea, Persian borage, and purslane extracts could help in antipsychotic-induced weight management in schizophrenia patients. Materials and Methods: This triple-blind, placebo-controlled study at Hijazi Psychiatry Hospital in Mashhad, Iran, involved 73 schizophrenia patients. Participants received either an herbal compound or a placebo, alongside their antipsychotic medication. The primary outcome was changes in body mass index (BMI), with secondary outcomes including waist-to-hip ratio (WHR), fasting blood sugar (FBS), HbA1c, lipid profile, blood pressure, appetite, quality of life, and psychotic symptom severity. Results: The herbal compound significantly reduced BMI (p