Ethosomes: nanostructures for enhanced skin penetration

The skin is a prominent and easily accessible organ in the human body. Despite providing the most straightforward and non-invasive drug administration method, the skin's limited permeability restricts the range of medications effectively delivered transdermally. The use of ethosomes as innovative vesicles for transdermal drug delivery has shown considerable promise in enhancing the permeation of drugs through the biological membrane. Ethosomes offer a preferable alternative to liposomes due to their ability to penetrate the skin more rapidly. Researchers have shown significant interest in ethosomes because of their exceptional capacity to deeply penetrate the skin, improve drug delivery, and achieve high entrapment efficiency. This study provides a comprehensive exploration of ethosomes as a drug delivery system. It aims to present detailed information on various aspects of ethosomes, including their manufacturing process, advantages, composition, properties, and applications in treating multiple diseases such as rheumatoid arthritis, psoriasis, hormonal imbalances, and other skin infections.