The Anti-proliferative and Pro-apoptotic Effects of Iranian Viper Venom (Vipera raddei kurdistanica) on Human Gastric Cancer Cells (C615) are Mediated by PI3K/AKT/mTOR Signalling Pathway Inhibition.

PubMed 2026 Open access

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Authors: Cyrus Jalili, Mona Pazhouhi, Mohammadreza Gholami, Fuzieh Khani Hemmatabadi, Keyvan Maleki
DOI: 10.22074/cellj.2026.2061544.1869
Cited by: 0

Abstract

Objective: venom on human GC cells (C615). Materials and Methods: ) concentration was evaluated using the TUNEL, annexin V/PI flow cytometry, and diphenylamine DNA fragmentation assays. Mitochondrial membrane potential (JC-1), cytosolic cytochrome c levels, and the expressions of apoptosis-related and PI3K/ AKT/mTOR pathway genes were measured. All experiments were performed in three independent biological replicates. Results: (P

Fields of Study & Subjects

Venomous Animal Envenomation and Studies Healthcare and Venom Research Toxin Mechanisms and Immunotoxins

Publication details

Journal / source
PubMed
Volume
27
Issue
1
Pages
1–9
Publication date
15 February 2026
Language
EN