N-Alkyl & N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors compound 25 ((3'R)-1'-{(1P)-5-amino-1-[2-(trifluoromethoxy)phenyl]-1H-pyrazole-4-carbonyl}-6-chloro-5-fluorospiro[[3,1]benzoxazine-4,3'-piperidin]-2(1H)-one)

R.R. Merchant; Natalia Chernyak; J.A. Lopez; P.P. Sharp; M. Mandal; J. Je; Alan W. Hruza; Paul Rearden; DA Tatosian; K. Lin; Joel D. Esmay; S. Yang; A. Cheng; Ken Ellsworth; T. Poiou; Patrick S. Fier; J. Hicks; Christopher J. Sinz; A. Ogawa

doi:10.2210/pdb10mw/pdb

N-Alkyl & N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors compound 25 ((3'R)-1'-{(1P)-5-amino-1-[2-(trifluoromethoxy)phenyl]-1H-pyrazole-4-carbonyl}-6-chloro-5-fluorospiro[[3,1]benzoxazine-4,3'-piperidin]-2(1H)-one)

Worldwide Protein Data Bank 2026 Dataset

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Authors: R.R. Merchant, Natalia Chernyak, J.A. Lopez, P.P. Sharp, M. Mandal, J. Je, Alan W. Hruza, Paul Rearden, DA Tatosian, K. Lin, Joel D. Esmay, S. Yang

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A. Cheng, Ken Ellsworth, T. Poiou, Patrick S. Fier, J. Hicks, Christopher J. Sinz, A. Ogawa

DOI: 10.2210/pdb10mw/pdb

Cited by: 0

Fields of Study & Subjects

Coagulation Bradykinin Polyphosphates and Angioedema Synthesis and biological activity Protease and Inhibitor Mechanisms

Publication details

Journal / source: Worldwide Protein Data Bank
Publication date: 28 January 2026
Document type: Dataset