N-Alkyl & N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 13 ((3'R)-1'-{5-amino-1-[(2S)-1,1,1-trifluorobutan-2-yl]-1H-pyrazole-4-carbonyl}-6-chloro-5-fluorospiro[[3,1]benzoxazine-4,3'-piperidin]-2(1H)-one)

R.R. Merchant; Natalia Chernyak; J.A. Lopez; P.P. Sharp; M. Mandal; J. He; Alan W. Hruza; Paul Rearden; DA Tatosian; K. Lin; Joel D. Esmay; S. Yany; A. Cheng; Ken Ellsworth; Tiffany Piou; Patrick S. Fier; J. Hicks; Christopher J. Sinz; A. Ogowa

doi:10.2210/pdb10qs/pdb

N-Alkyl & N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 13 ((3'R)-1'-{5-amino-1-[(2S)-1,1,1-trifluorobutan-2-yl]-1H-pyrazole-4-carbonyl}-6-chloro-5-fluorospiro[[3,1]benzoxazine-4,3'-piperidin]-2(1H)-one)

Worldwide Protein Data Bank 2026 Dataset

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Authors: R.R. Merchant, Natalia Chernyak, J.A. Lopez, P.P. Sharp, M. Mandal, J. He, Alan W. Hruza, Paul Rearden, DA Tatosian, K. Lin, Joel D. Esmay, S. Yany

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A. Cheng, Ken Ellsworth, Tiffany Piou, Patrick S. Fier, J. Hicks, Christopher J. Sinz, A. Ogowa

DOI: 10.2210/pdb10qs/pdb

Cited by: 0

Fields of Study & Subjects

Coagulation Bradykinin Polyphosphates and Angioedema Synthesis and biological activity Computational Drug Discovery Methods

Publication details

Journal / source: Worldwide Protein Data Bank
Publication date: 2 February 2026
Language: EN
Document type: Dataset