FORMULATION AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLET OF KETOROLAC TROMETHAMINE PREPARED USING HPMC K100M AND XANTHAN GUM

Objective: The primary goal of this research was to create and assess the efficacy of ketorolac tromethamine (KT) controlled release matrix tablets formulated with Xanthan gum and polymers, hydroxypropylmethylcellulose (HPMC) K100M. Methods: A 3×3 factorial design was employed, and the matrix tablets were tested. All of the manufactured tablets met the requirements for hardness, friability, weight fluctuation, medicine content, and thickness. Results: The optimized formulation (F6, containing 36 mg HPMC K100M and 36 mg Xanthan Gum) showed 97.58% drug release over 24 h, fitting the Korsmeyer–Peppas model (R²=0.9964) with non-Fickian diffusion (n=0.5922). The optimized formulation F6 remained stable under accelerated conditions for 3 months. Conclusion: The study concluded that KT matrix tablets, particularly batch F6 with equal ratios of HPMC K100M and Xanthan gum, showed optimal drug release (94.52% in 24 h) and excellent stability.