HESPERIDIN INHIBITS THE ACQUISITION AND EXPRESSION OF SENSITIZATION TO THE LOCOMOTOR STIMULANT EFFECT OF ETHANOL IN SWISS ALBINO MICE

Objectives: The objective of the present study was to investigate the influence of hesperidin on both the acquisition (development) and expression (manifestation) of sensitization to ethanol’s locomotor stimulant effects in Swiss albino mice. By examining these parameters, this study aims to elucidate the possible therapeutic role of hesperidin as a natural neuroprotective agent for preventing or attenuating ethanol-induced neurobehavioral adaptations and addiction. Methods: The presenter search set out to examine the effect of hesperidin on ethanol-induced behavioral sensitization in Swiss albino mice. Results: The results revealed that treatment with hesperidin across all doses of 4 mg/kg, 8 mg/kg, and 16 mg/kg notably decreased the ethanol-induced count (p