THIOSEMICARBAZONE – BASEDZN(II), CU(II),NI(II) AND CO(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION AND EVALUATION OFANTIBACTERIAL AND ANTIFUNGALACTIVITIES

Objective: The aim of the research is to synthesis, characterize and evaluate the biological activity of Cu(II), Zn(II), Co(II) and Ni(II) complex from thiosemicarbazone (TSC) ligands. Methods: The ligands were synthesised by refluxing thiosemicarbazide with 2-acetylfuran in water, forming a dark brown product. The complexation reaction involved stirring aqueous solutions of Cu(II), Zn(II), Co(II) and Ni(II) salts with an ethanolic solution of Schiff base ligand. These metal complexes were tested for their anti-fungal and anti-bacterial activity against selected fungal and bacterial strains. Results: The complexes were studied using infrared (IR), nuclear magnetic resonance and Mass spectroscopy. IR spectra showed that the nitrogen (of azomethine) and atoms of sulfur coordinated the ligands. Metal complexes activity has superior antifungal and antibacterial as compared to free ligands, perhaps due to lipophilicity and chelation. Zinc(II) complexes had the highest activity, followed by Cu(II), Ni(II) and Co(II) complexes, demonstrating the role of the central metal ion in biological characteristics. Conclusion: The obtained outcomes specified that the produced complexes of metal with TSC may be attractive candidates for novel antibacterial and antifungal medicines, requiring additional biological investigations.