THE SIGNIFICANCE OF PHYTOCHEMICALS IN THE PROCESS OF LINGA CHENDOORAM PREPARATION

Objective: We know that most of the metals are toxic , that raised a great concern among people. The siddhars' knowledge of Iatro-chemistry, minerals, metals and plants was stupendous. Hence, in this project attempts are made to standardize linga chendooram and to prove that the end product is free from metals. Linga chendooram is a herbo-metallic preparation, having Mercury as its chief constituent. The Siddhars have devised the preparation in such a way that makes it bio-compatible and non-toxic. Methods: To prove, this research works select two methods for preparation and carry out standardization and validation studies on Zeta sizer, GCMS, FTIR, AAS, TGDTA and SEM analysis. Results:Standardization results indicates that it preparation was fully completed as per literatures. GC-MS and FTIR results observed that the amine group present in final product have complex with cinnabar.AAS results point out medicines were free from toxic metals.The average size of the both products determined by Zeta sizer Nano size and was found to be 832.7nm and 676.7nm respectively. The TG-DTA and Zeta-sizer results conclude that the product is stable and can be used for biological system infusions. The SEM images confirmed the transformations in the morphology of the starting material which is due to the preparation process. The final product is coagulated which serves as evidence to complex formation. Conclusion: This research work conclude, the toxic mercury may be converted into biocompatible form due to the chemical transformations and surface morphology changes that occurred during the process.