DEVELOPMENT AND IN VITRO ANTIDIABETIC ASSESSMENT OF SUSTAINED RELEASE VILDAGLIPTIN TABLETS USING NATURAL POLYMERS THROUGH DIPEPTIDYL PEPTIDASE-4 INHIBITION

Objectives: The objective of the study is to develop sustained-release (SR) vildagliptin tablets using natural mucilages from Mimosa pudica and Tinospora cordifolia and to evaluate their physicochemical properties, release kinetics, and in vitro antidiabetic activity. Methods: Mucilages were characterized and used as release modifiers in SR tablets. Pre- and post-compression parameters were assessed per pharmacopeial standards. In vitro drug release was measured for 12 h (n=6) and fitted to kinetic models. Dipeptidyl peptidase-4 inhibition and half maximal inhibitory concentration (IC50) values were determined for pure drug and the optimized formulation. Results: The mucilages exhibited good flow (angle of repose 27–35°; Carr’s index 13–19%). All batches met pharmacopeial limits (hardness 5.0–5.6 kg/cm2; friability