SYNTHESIS, CHARACTERIZATION OF SOME NOVEL SCHIFF BASE LIGAND METAL COMPLEXES: SPECTRAL, THERMAL ANALYSIS, XRD AND ANTIMICROBIAL STUDIES

Objective: The aim of the research is to synthesize and characterize Ni(II), and Co(II) complexes with a Schiff base ligand, and evaluate their anti-fungal andantibacterial activity. Methods: The ligand was synthesized by refluxing 3,5-diiodosalicyaldehyde and 2-amino-4-hydroxy-6-methylpyrimidine in ethanol, forming a yellow product. The complexation reaction involved stirring ethanolic solutions of Ni(II), and Co(II) salts with a Schiff base ligand. Thermal decomposition of Ni(II), and Co(II) complexes was analyzed under nitrogen, heating at 30 °C/min, measuring weight loss from ambient temperature to 1000 °C. The Antifungal activity and antibacterial activity of the synthesized compounds wereexamined using reported methods. Results: Ni(II), and Co(II) complexes with a Schiff base ligand were synthesized. Analyzed through Fourier-transform infrared spectroscopy (FTIR), Ultraviolet-visible (UV-vis) and physiochemical tests and confirmed the structures. Magnetic susceptibility and electronic spectra suggested geometries, supported by thermogravimetric data. Antibacterial tests revealed complexes had higher activity than ligands, and also showed anti-fungal properties. The ligand and its complexes were screened for their anti-fungal and antibacterial activity against Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme, Aspergllus flavus and Escherichia coli, Salmonella typhi, Staphylococcus aureus, B. subtilis. The result indicated that the complexes exhibited good antifungal and antibacterial activities. Conclusion: Ni(II), and Co(II) Schiff base complexes were synthesized, showing octahedral geometries. They exhibited thermal stability and strong antibacterial activity, antifungal outperforming the ligand alone.