A Randomised Open Labelled Comparative Clinical Study to Evaluate Effect of Hamsapadi (Adiantum lunulatum Burm) and Gokshura (Tribulus terrestris Linn) in Pittaja Mutrakruchra with Special Reference to UTI

Urinary tract infections (UTIs) are common, particularly among females, and can be correlated with Pittaja Mutrakruchra in Ayurveda, which presents with symptoms such as Peeta mutrata, Sadaha mutrata, Saruja mutrata, and Sarakta mutrata. Gokshura (Tribulus terrestris Linn.) is a well-documented herb with Mutrala properties and is widely used in urinary disorders. Hamsapadi (Adiantum lunulatum Burm.) is described in classical texts as Pittashamaka and Raktaprasadaka, suggesting its therapeutic potential in similar conditions, though it lacks sufficient clinical evaluation. Hence, the present study aimed to comparatively evaluate the efficacy of Gokshura and Hamsapadi in the management of Pittaja Mutrakruchra. A randomized clinical trial was conducted on 40 subjects presenting with lakshanas of Pittaja Mutrakruchra. The subjects were randomly allocated into two groups: Group A (n = 20) received Gokshura moola churna and Group B (n = 20) received Hamsapadi panchanga churna for a period of 15 days. Subjective and objective parameters were assessed before and after treatment and statistically analyzed. Both groups showed statistically significant improvement in subjective and objective parameters; however, Group A demonstrated comparatively better therapeutic outcomes. Phytochemical analysis of both trial drugs revealed the presence of alkaloids, flavonoids, tannins, carbohydrates, and other plant metabolites. It can be concluded that both Gokshura moola churna and Hamsapadi panchanga churna are effective in the management of Pittaja Mutrakruchra, with Gokshura showing superior efficacy