Biosynthesis with Antibacterial, Anticancer, and Antioxidant Evaluation of Silver Nanoparticles Using Cucumis melo var. flexuosus Extract

Background and Objective: Multidrug resistant (MDR) bacteria, specially when a etiological agents of burn infections, are currently a?growing and concerning clinical problem which emphasizes the necessity for development of novel antimicrobial agents. Green synthesis of silver nanoparticles (AgNPs) using plant materials has gained more attention because they exhibit?promising antimicrobial, antioxidant and anticancer applications. The present work was designed to develop eco-friendly method for synthesis of AgNPs and also investigate their antibacterial potential against MDR?pathogens. Methodology: The AgNPs were prepared with?extract of Cucumis melo var. flexuosus and subsequently characterized. Their in vitro antibacterial, cytotoxic and antioxidant potential was screened by agar diffusion?(antibacterial), MTT assay cytotoxic and DPPH free radical scavenging activity antioxidant. Results: The synthesized AgNPs also?had a broad antibacterial effect, with Gram-negative bacteria being the most susceptible. They also showed tumor?selective cytotoxicity for breast cancer cells and good antioxidant activity, better than that of ascorbic acid. Conclusion: C.?melo var. flexuosus had potential applications for biomedical research as they could significantly inhibit resistant bacterial?growth, possess marked antioxidant activity, and displayed apparent selective anticancer capacity.