Quantification of insulin glargine and its metabolites from human plasma using liquid chromatography tandem mass spectrometry
Abstract
Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycaemia caused by Type 1 and Type 2 diabetes. Insulin Glargine injected subcutaneously is metabolized in the liver into two active metabolites with similar activity to insulin: 21a-Gly-human insulin (M1) and 21a-Gly-des-30b- threonine insulin (M2), with M1 being the predominant metabolite.
Fields of Study & Subjects
Analytical Methods in Pharmaceuticals
Biosimilars and Bioanalytical Methods
Diabetes Management and Research
Publication details
- Journal / source
- International Journal of Multidisciplinary Trends
- Volume
- 8
- Issue
- 3S
- Pages
- 31–35
- Publication date
- 1 March 2026
- Language
- EN