Single-stage sequestrectomy with STIMULAN in chronic osteomyelitis: Impact on sinus tract recurrence and surgical site infection

Background: Chronic osteomyelitis is a complex bone infection with sequestrum and sinus formation. This study evaluates outcomes of single-stage sequestrectomy with antibiotic-loaded STIMULAN, focusing on sinus tract recurrence and surgical site infection (SSI). Methods: Prospective observational study at Amandeep Hospital, Amritsar (March 2021-March 2022), N=67. Single-stage sequestrectomy and debridement with vancomycin-gentamicin loaded STIMULAN; 12-month follow-up for sinus recurrence, SSI, eradication, and functional outcomes. Results: Infection eradication 91%; sinus recurrence 6%; SSI 7.5%; transient sterile drainage 11.9%. ESR/CRP normalized by 6 weeks (p