A Comprehensive review on pharmacological and therapeutic potential of two commonly consumed leaves of Amaranthus in Bengali cuisine: Amaranthus cruentus and Amaranthus viridis

Amaranthus cruentus and Amaranthus viridis are considered indispensable leafy vegetables and pseudo-cereals, both with their traditional applications as well as increasing scientific interest, and they also represent plants that are known in various countries; and also their growth as pseudo-cereals. They are nutrient laden and rich in a variety of phytochemicals (phenolic acids, flavonoids, betalains, carotenoids, saponins, and bioactive peptides) that have the potential as functional foods and pharmacological properties of their compounds for food. Studies in 2020-2026 demonstrated antioxidant activity in these species including direct radical scavenging, metal chelation, protection against lipid peroxidation, and activation of internal defense systems such as Nrf2-ARE. Antioxidant function is increasingly considered the main mechanism underlying their anti-inflammatory, antidiabetic, antihypertensive, cardioprotective, neuroprotective, hepatoprotective, antimicrobial, and anticancer effects. This manuscript summarizes recent information on nutritional and phytochemical characteristics of A. cruentus and A. viridis, describes the antioxidant-driven pharmacological properties, and concludes with the knowledge gaps. It provides future clinical implications, bioavailability studies, as well as a product development plan.