Antioxidant and antihyperlipidemia effects of artichoke on hyperlipidemia-induced male rabbits

Hyperlipidemia is one of the most important metabolic diseases related to oxidative stress, hepatic damage and cardiovascular risks. The aim of this study was to evaluate the possible protective effects of artichoke (Cynara scolymus L.) fruits powder, atorvastatin and their combination on lipid profile, oxidative stress markers, liver enzymes, heart enzymes, physiologic parameters (hemodynamic), as well as histopathology & gene expression in rabbit diet model of hyperlipidemia. Forty New Zealand white male rabbits were equally and randomly assigned into five groups (N=5/group): negative control; received standard diet [Negative/G1]; positive hyper lipid emic control [Positive-G2]; induced by feeding of HFD, animals were fed high fat diet (HFD); artichoke treated-group [G3 n=5] and atorvastatin treated group [Atorvastatin 40 mg/kg/G4] in addition to combined treatment group of artichoke together with atorvastatin where there was drug interaction between them [Artichoke+ Atorvastatin /G5]. Hyperlipidemia was induced by 4 weeks of HFD nutrition. Serum lipid profile, malondialdehyde (MDA), total antioxidant capacity (T-AOC) were estimated while cardiac troponin-I, by CRD design and LSD test (p