Study of carcinogenesis risks in different variants of coinfection with human papilloma virus and other sexually transmitted infection agents

Sexually transmitted infections (STIs) are prevalent worldwide and pose a significant challenge to national healthcare systems. Human papillomavirus (HPV) annually causes over 600,000 cases and 350,000 deaths from cervical cancer (CC). Coinfections with HPV and other STIs often potentiate the development of dysplastic processes and CC. The role of STI and HPV coinfection in carcinogenesis and the impact of multiple HPV infections on the development of CC have been poorly studied. Aim of the study : to assess the prevalence and risks of carcinogenesis in various variants of coinfection with human papillomavirus and other sexually transmitted infection agents. Materials and methods . A total of 9,310 HPV-positive women with STIs and/or other diseases were examined. Detection of 14 HPV genotypes was performed using PCR. The diagnosis of cervical intraepithelial neoplasia (CIN) was established based on extended colposcopy and cytological examination. Methods: PCR, clinical, epidemiological, and statistical methods. Results and discussion . In case of coinfection with STIs, the prevalence of HPV genotypes 16, 18, and 45 had statistically significant differences (32.0%, 9.7%, and 11.4%, respectively, p