Analysis of the effectiveness of repeated courses of tuberculosis chemotherapy after inefficient courses

The aim : to study the effectiveness of repeated chemotherapy courses after ineffective courses. Materials and methods . A retrospective documentary study of the general population (n=817) of all registered newly diagnosed cases of tuberculosis in the Kaluga region in 2019–2023 was conducted. Two groups of patients were compared: patients with an effective outcome of chemotherapy (group 1, n=560) and patients with an ineffective outcome of chemotherapy, for whom the repeated course was effective (group 2, n=72). Results and discussion . A high risk of registering an ineffective course of chemotherapy and prescribing a repeated course is noted in unemployed patients (52.8% versus 38%, p=0.0158) and homeless persons (11.1% versus 2.9%, p=0.003). Among patients with an ineffective chemotherapy course and a repeated effective one (group 2), bacterial excretion (91.7% versus 49.3%, p