Evaluation of the Chronic Toxicity and Carcinogenicity (C55221D) of Sodium Fluoride (7681-49-4) in F344 Rats (Ionizing Radiation and Drinking Water Study)

In an effort to examine the effect of exposure to sodium fluoride on the incidence of bone tumors induced by ionizing radiation, the femoral-tibial joint of the left hind limb of 100 male F344 rats was irradiated with 3000 R from a 137Cs source and the animals divided into two groups of 50. One group was then administered drinking water containing 250 ppm sodium fluoride for two years while the other group received plain deionized water.