Factors Influencing Gingival Overgrowth in Patients on Amlodipine and Nifedipine: A Systematic Review

Gingival overgrowth is a common and well-documented condition associated with the use of antihypertensive drugs, most notably amlodipine and nifedipine. This review aims to analyze various factors based on data collected from multiple studies and to summarize the findings to determine the influence of different variables. A slight male predominance was observed, and most cases occurred among patients aged between 50 and 60 years. The number of patients using amlodipine was higher than those using nifedipine. Gingival overgrowth most frequently occurred at doses below 5 mg per day, with the duration of drug intake most commonly ranging between 12 and 36 months. The analyzed factors included age, gender, type of drug, dosage, and duration of treatment.