1133-OR: Safety, Tolerability, and Pharmacokinetics of Once-Weekly Mazdutide in Chinese Adolescents with Obesity: A Phase 1b Trial

Diabetes 2026

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Authors: CHUNXIU GONG, Xin Ni, Jiajia Chen, Wei Zhao (14321), Shuang Liang, HUI YAO, Bingyan Cao, DENG Huan, JIAOWEI LU, Han Han‐Zhang, Li Li (14993), Hanbo Hu
+4 more CHENG LINGGE, YANQI WANG, YULIA JIN, Lei Qian
DOI: 10.2337/db26-1133-or
Cited by: 1

Abstract

Introduction and Objective: Given the established safety and efficacy of mazdutide in adults with obesity, this study evaluated the safety, tolerability, and pharmacokinetics (PK) of the once-weekly GLP-1/glucagon receptor dual agonist in Chinese adolescents with obesity. Methods: In this multicenter, randomized, double-blind, placebo-controlled Phase 1b trial (NCT06536023), 36 Chinese adolescents (12 to

Fields of Study & Subjects

Diabetes Treatment and Management Pharmacology and Obesity Treatment Diabetes Management and Research

Publication details

Journal / source
Diabetes
Publisher
American Diabetes Association
Volume
75
Issue
Supplement_1
Publication date
5 June 2026
Language
EN