Sex Hormones and Cardiovascular Risk in Type 2 Diabetes: Cohort Study of the Look AHEAD Trial

Diabetes Care 2026 Open access

Read full text
Authors: Teresa Gisinger, Jiahuan Helen He, Chigolum P. Oyeka, Jianqiao Ma, Nityasree Srialluri, Mark Woodward, Erin D. Michos, Rita R. Kalyani, Jeanne M. Clark, A. Kautzky-Willer, Dhananjay Vaidya, Wendy L. Bennett
DOI: 10.2337/dc25-2465
Cited by: 2
References: 18

Abstract

OBJECTIVE: To investigate the association of sex hormones at baseline and 1 year after a lifestyle intervention on cardiovascular (CV) risk in type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: This prospective study, following the Look AHEAD: Action for Health in Diabetes (Look AHEAD) trial, of 2,260 adults with T2D, included measurements of sex hormones and sex hormone binding globulin (SHBG). Baseline levels and 1-year changes were divided into sex-specific tertiles to assess the association with CV events (n = 488 events) and weight loss interactions. RESULTS: In men, higher baseline total testosterone was associated with lower CV risk (hazard ratio [HR] = 0.74; 95% CI 0.56-0.97). In men with ≥7% weight loss, SHBG increases were inversely associated with CV risk (HR = 0.47; 95% CI 0.26-0.85). In men with

Fields of Study & Subjects

Hormonal and reproductive studies Diabetes Cardiovascular Risks and Lipoproteins Menopause: Health Impacts and Treatments

Publication details

Journal / source
Diabetes Care
Publisher
American Diabetes Association
Volume
49
Issue
3
Pages
497–501
Publication date
26 January 2026
Language
EN