Enzymatic 2-Hydroxybutyrate Measurement for Dysglycemia Screening Beyond Conventional Fasting Measures

Diabetes Care 2026

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Authors: Christoph Strohhofer, Katharina Eberhard, Barbara Obermayer-Pietsch, DAVID STADLER, PETER HERZOG, Nora Schwegel, Viktoria Santner, Tobias Niedrist, Markus Herrmann, Dirk von Lewinski, Andreas Zirlik, Harald Sourij
+2 more NICOLAS VERHEYEN, Thomas R. Pieber
DOI: 10.2337/dc26-0567
Cited by: 1
References: 17

Abstract

OBJECTIVE: We investigated whether fasting 2-hydroxybutyrate (2-HB), measured by a novel enzymatic assay (XpressGT), can provide incremental discrimination of dysglycemia beyond routine fasting measures. RESEARCH DESIGN AND METHODS: Associations of 2-HB with dysglycemia were assessed in the total Biomarkers of Personalized Medicine cohort and in the prespecified subcohort with fasting plasma glucose (FPG)

Fields of Study & Subjects

Diet and metabolism studies Diet Metabolism and Disease Bariatric Surgery and Outcomes

Publication details

Journal / source
Diabetes Care
Publisher
American Diabetes Association
Volume
49
Issue
8
Pages
1374–1379
Publication date
8 June 2026
Language
EN