Medication Adherence and Glycemia Reduction in Type 2 Diabetes: a Subanalysis from the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study

2026 Open access

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Authors: JEFFREY S. GONZALEZ, Hui Wen, NICOLE M. BUTERA, Diane Uschner, Heidi J Krause-Steinrauf, Michaela R. Gramzinski, Deborah J. Wexler, Helen Petrovitch, Claire J. Hoogendoorn, Gladys Crespo-Ramos, Caroline A. Presley, Basma N. Fattaleh
+3 more Violet S. Lagari, Elizabeth A. Walker, Andrea Cherrington
DOI: 10.2337/figshare.30657905
Cited by: 0

Abstract

Objective: To address previous inconsistencies in reports of differential adherence to diabetes medications, we examined medication adherence and evaluated treatment group differences in a subset of participants in the GRADE study. Research Design and Methods: GRADE participants (T2DM7.5%) glycemic outcomes. Results: Overall, mean (SD) adherence was high over 3 years of follow-up at 88.7(10.01) and decreased slightly by 3 years relative to baseline (-2.0±14.7,p

Fields of Study & Subjects

Medication Adherence and Compliance Diabetes Treatment and Management Diabetes Management and Education

Publication details

Publication date
20 January 2026