Molecular Classification in a Cohort of Occupational Dermatological Patients: Diagnostic Results and Course of Ability to Work and Sick Leave Over Two Years

Hand eczema is the most common occupational skin disease (OSD), often leading to sick leave or job termination. Standard diagnostic procedures are often ambiguous. Molecular classification has been described to improve differentiation between eczema and psoriasis, which is the most common differential diagnosis. Since 2020, a cohort of 287 patients with suspected, occupational hand and/or foot dermatoses (eczema or psoriasis) has been established in Germany. The current analysis focuses on descriptive results on the days of absence from work, occupational retention and legal recognition of OSD after 24 months. A total of 38.9% of the patients did not receive a distinct clinical diagnosis, while molecular diagnostics provided results in 93.1% of these cases. Sick leave days significantly decreased over 2 years (p