Ketoprofen lysine salt for relieving acute pain: a multi-regression analysis

INTRODUCTION: Acute pain is a common symptom that requires prompt and adequate treatment. Ketoprofen lysine salt (KLS) is a non-steroidal anti-inflammatory drug (NSAID) able to rapidly relieves mild-moderate acute pain in children and adolescents. The present study aimed to perform a meta-analysis of controlled studies on this issue. EVIDENCE ACQUISITION: A scientific literature search selected three controlled trials concerning the KLS use in patients with acute pain. A meta-regression analysis was performed. EVIDENCE SYNTHESIS: The overall trend, modeled through weighted linear regression, confirms a significant time-dependent reduction in pain scores by KLS. The onset of action is quick and analgesic effect is prolonged. CONCLUSIONS: This meta-regression analysis showed that KLS could relieve mild to moderate acute pain promptly and in a prolonged manner over time, as desired by a patient with acute pain.