The relationship between vitamin D levels and the incidence of polycystic ovary syndrome: a cross-sectional study

BACKGROUND: Polycystic ovary syndrome (PCOS) is common in obese women. Obesity is the cause of low serum vitamin D levels because vitamin D is fat-soluble and stored in adipose tissue. Meanwhile, high nutritional status is a risk factor for PCOS so that the possibility of the underlying mechanism of the disease is due to vitamin D deficiency. This study aimed to analyze the relationship between vitamin D levels and the incidence of PCOS.METHODS: This is an observational study with a cross-sectional design. The sample consisted of women who underwent examinations at the teaching hospital and its network, the Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University (Makassar, Indonesia), with a diagnosis of PCOS and without PCOS. Serum vitamin D levels were measured using ELISA kits. Statistical analysis used χ2, Mann-Whitney Test, and ANOVA at a significance level of 5%.RESULTS: A total of 88 women were collected consisting of 44 women with PCOS and 44 women without PCOS. Vitamin D levels in women with PCOS were significantly lower than those in women without PCOS with a P value