Comparative mucoadhesion of alginate-polysaccharide combinations in reflux-related diseases

BACKGROUND: Esophageal mucosal injury is a key component in the pathogenesis of reflux-related disorders, including gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux disease (LPRD), conditions in which epithelial barrier impairment is frequently observed endoscopically. Such injury is mainly driven by prolonged exposure to gastric acidity. Current therapeutic approaches rely on mucoadhesive agents to protect epithelial surfaces, with alginates and natural polysaccharides widely recognized for their safety and effectiveness.METHODS: This in-vitro study evaluated the mucoadhesive capacity of a medical device (product A) composed of magnesium alginate, carbonate, bicarbonate, and natural polysaccharides from Opuntia ficus-indica and Olea europaea extracts. Mucoadhesion was assessed over time using a reconstructed human esophageal epithelium model. Product A was compared with hyaluronic acid (benchmark) and two marketed formulations (products B and C).RESULTS: Across all evaluated time points, product A showed greater affinity for the esophageal epithelium than hyaluronic acid and both commercial comparators. CONCLUSIONS: The findings indicate that the combination of natural polysaccharides with alginates strengthens mucoadhesive properties and improves mucosal protection. These results support the potential application of product A in the management of reflux-related diseases.