Current ways to prevent the development of coronary artery disease of the transplanted heart

Background. Coronary artery disease of the transplanted heart (CADTH) is the most frequent complication and cause of death in patients living more than a year after heart transplantation (HT). The development of effective methods for CADTH prevention remains one of the urgent tasks of transplantology. Up-do-date methods of ex vivo machine perfusion, which allow the CADTH prevention and ensure longer cardiac allograft survival and function. Objective. To make a review of promising methods for CADTH prevention to prolong the cardiac allograft survival and function. Material and methods. Sources from 2000 to 2024, retrieved from PubMed, Google Scholar, eLIBRARY.RU. Conclusion. Prevention of cardiac graft vasculopathy at early stages, namely during ex vivo machine perfusion, allows reducing the risk of the disease onset in the postoperative period. Machine perfusion of the cardiac graft is not only a way of CADTH prevention, but possibly the key way of prolongation of the graft functioning.