Efficacy of a Novel Phyto Placenta Complex on Ovarian Physiological Age, Dermal Microstructure, and Menopausal Symptoms: A 12-Week Randomized, Double-Blind, Placebo-Controlled Pilot Trial

This 12-week randomized, double-blind, placebo-controlled pilot trial evaluated the effects of a novel Phyto Placenta Complex on ovarian physiological function, dermal microstructure, and menopausal symptoms in perimenopausal women aged 45–55 years. Twenty-five participants were randomly assigned to receive either 230 mg/day of the Phyto Placenta Complex (n = 13) or placebo (n = 12). Serum inhibin B levels declined in the placebo group (−12.4% from baseline), whereas levels were maintained in the treatment group (48.5 ± 10.1 pg/mL). Regression analysis indicated a shift toward a younger ovarian physiological profile by approximately 4.7 years relative to chronological age in the treatment group (p < 0.05). Significant improvements were also observed in wrinkle depth, skin hydration, elasticity, and melanin index, as well as a 62.3% reduction in total Modified Kupperman Index scores. These findings suggest that daily supplementation with 230 mg of Phyto Placenta Complex preserves ovarian endocrine function and improves systemic menopausal outcomes, potentially mediated by efficient in vivo conversion to S-equol and ERβ-selective signaling.