Network Pharmacology-Based Mechanism Exploration of Buyang Huanwu Decoction in Chronic Heart Failure

Exploring the potential molecular mechanism of Buyang Huanwu Decoction in the treatment of chronic heart failure based on network pharmacology. Methods: The effective active ingredients of Buyang Huanwu Decoction were screened by searching TCMSP database, Chinese medicine Database@Taiwan and literature, and the targets of the effective active ingredients were predicted by SEA database and Binding Database. The targets related to chronic heart failure were obtained by Genecards, TTD, OMIM, Drugbank and PharmGkb Database, and the intersection targets of Buyang Huanwu Decoction and CHF were obtained. Cystoscape3.8.0 was used to construct a compound - disease - intersection target network diagram. The String database was used to construct PPI network, and R4.0.3 software was used to perform GO function enrichment analysis and KEGG signal pathway enrichment analysis for the intersection targets. Results: 1) A total of 104 chemical components and 841 targets were screened out in Buyang Huanwu Decoction. A total of 2908 targets were collected for chronic heart failure. There were 404 intersection targets of Buyang Huanwu Decoction and chronic heart failure. 2) Through PPI network, 28 core targets were screened out. 3) GO biological enrichment results showed 3964 GO entries; KEGG analysis co-enriched PI3K-Akt,MAPK, ect. 191 signaling pathways. Conclusion: Buyanghuanwu decoction can treat chronic heart failure through multi-component, multi-target and multi-channel mechanism.