Randomized, Double-Blind, Controlled Trial of Memory and Attention Enhancement in Adolescents via DHA-Enriched Fish Oil Combined with Galangal Extract

This randomized, double-blind, controlled trial aimed to explore the effects of DHA-enriched fish oil alone or combined with galangal extract on memory and attention in adolescents. A total of 68 adolescents aged 12-18 years were recruited, with 66 completing the 90-day intervention. They were divided into four groups: high-dose combo group (HCG, 600 mg fish oil plus galangal extract daily), high-dose group (HG, 600 mg fish oil daily), low-dose group (LG, 300 mg fish oil daily), and control group (CG, placebo). Participants took the test product for 90 consecutive days, and their attention and memory levels were assessed using the sub-item memory scales and MQ task and the IQ test at baseline (D0), day 30 (D30), and day 90 (D90). Repeated-measures analysis of variance revealed that the combined intervention group exhibited significant improvements in all core memory subscale scores and MQ values. Specifically, at D30, the HCG showed marked increases in all memory subscale scores (P