CHRONIC CORONARY SYNDROME – STABLE ANGINA: NUTRITIONAL COMPLEX (DHA 400 mg + POLYCOSANOL 20 mg) AS A SUPPLEMENT TO ANTIANGINAL AGENTS AND STATIN THERAPY

The aim of the study was to establish the pharmacodynamics, therapeutic efficacy and safety of the nutraceutical Cardionevrin Forte (DHA 400 mg + Policosanol 20 mg) in the treatment of patients with chronic coronary syndrome – stable angina pectoris, NYHA FC III with concomitant arterial hypertension.Material and methods. This study examined the therapeutic efficacy of the nutraceutical complex Cardioneurin Forte against the background of standard therapy. The comparison group consisted of patients who received only standard therapy (control group). The effectiveness of treatment was monitored by clinical observation, electrocardiograms, transthoracic echocardiograms, speckle tracking echocardiography (Speckle Tracking EchoCG) (if necessary), lipidograms (total cholesterol, low-density lipoprotein, high-density lipoprotein, non-high-density lipoprotein cholesterol, triglycerides), coagulograms, biochemical blood analysis, dose-loaded physical exercise tests, and 6-minute walk tests.Statistical analysis of the study results was performed using Microsoft Excel 2021 spreadsheets and Statistica v12.0 statistical software packages (Stat Soft, USA) using parametric and non-parametric analysis methods.Results. Additional positive clinical, functional and lipid-lowering effects of treatment with CCS – stable angina pectoris were revealed. The most pronounced positive effect of the studied complex (standard therapy + Cardionevrin Forte) was on increasing HDL cholesterol levels (+56.4%) and decreasing non-HDL cholesterol levels (-40.7%). Less pronounced is the reduction in triacylglycerol levels (-21.7%) and total cholesterol (-24.3%).Conclusions. Supplementing standard therapy for patients with CCS - stable angina pectoris with the nutraceutical complex Cardionevrin Forte is appropriate and effective. The nutraceutical complex Cardionevrin Forte (DHA 400 mg + Policosanol 20 mg) is well tolerated and does not cause serious side effects or those that require discontinuation of the drug and specific treatment.